Glove on your right hand, a left-handed version of a drug wouldn’t be able to fit Just as you wouldn’t be able to fit a left-handed But the way they are arranged in space can drasticallyĬhange the effects they have in the body. Usually these mirror-image versions have very similar properties because they share The same, they don’t overlap when you put one on top of the other. Your hands are also nonsuperimposable mirror images of each other. Theseĭrugs are called chiral compounds - meaning they exist as two nonsuperimposable mirror images. Many drugs have the same atoms and bonds but are arranged differently in space. Turns out, it may be because two different forms were used - while one may help with cognition and memory, the other may be toxic to the nervous Has been a scientific mystery why clinical trials on using resveratrol to treat Alzheimer’sĭisease have had inconsistent results. My research has focused on one such compound found in red grapes and peanuts, resveratrol. Because the two versions can convert back and forth in the body, it’s dangerous to take either form of thalidomide while pregnant. While one form, or isomer, of thalidomide has a sedative effect, the other is thought to cause abnormal Some compounds have a dark twin with the same molecular formulaīut different 3D structure – and this can have consequences for what they do or don’tĬonsider the tragic story of thalidomide, a morning sickness drug that caused thousands of birth defects and miscarriages. The effects a drug or chemical compound have on the body depend on how its atoms areĪrranged in space. Mathew writes for The Conversation on how these compounds are arranged in space canĭrastically change the effects they have in the body. Theseĭrugs are called chiral compounds - meaning they exist as two mirror images. Sajish Mathew, drugs have the same atoms and bonds but are arranged differently in space. Posted on: AugUpdated on: August 16, 2022
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